The Assassin's Creed is a short comic, focusing on a mission of Altaïr Ibn-La'Ahad in Acre. While the comic is drawn from Altaïr's perspective, it also features dialogue from Al Mualim, who does not make a physical appearance in the narrative.

Assassin's Creed showed two side-stories of Altaïr Ibn-La'Ahad and Desmond Miles.

The comic book, consisting of three issues, followed the journey of the Russian Assassin Nikolai Orelov during the late 19th and early 20th centuries, whose genetic memories were viewed by his present-day descendant Daniel Cross.